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Hasan Mukhtar, PhD
Helfaer Professor of Cancer Research
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Link to: Full CV |
BS Physics, Chemistry, Math - Lucknow University, India, 1965
MS Biochemistry, Lucknow University, India, 1967
PhD Biochemistry, Kanpur University, India (Thesis: Chemical Studies on Drug Metabolism in Relation to Enzyme Induction), 1971
Our research focus is cancer prevention and to establish the utility of naturally occurring dietary substances in chemoprevention of prostate and skin cancers. For these studies cellular and molecular approaches in cell culture systems and intervention studies in transgenic mouse models are performed. Chemopreventive efficacies of many dietary substances and molecular targests of their effects are examined. Our long range goal is to establish a mechanistic basis for developing novel approaches for prevention of skin and prostate cancers.
Farrukh Afaq, PhD (Associate Scientist)
Vaqar Adhami, PhD (Associate Scientist)
Mohammad Saleem Bhat, PhD (Assistant Scientist)
Jeremy J. Johnson (Project Assistant)
Naghma Khan, PhD (Research Associate)
Imtiaz Siddiqui, PhD (Research Associate)
Deeba Syed, MBBS (Research Specialist)
Afaq F, Syed DN, Malik A, Hadi N, Sarfaraz S, Kweon MH and Mukhtar H:Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects HaCaTkeratinocytes against UVB-induced oxidative stress and apoptosis. J Invest Dennatol127: 222-232,2007.
Syed DN, Khan N, Afaq F and Mukhtar H: Chemoprevention of prostate cancerthrough dietary agents: progress and promise. Cancer Epidemiol Biomarkers Prev16:2193-2203,2007.
Khan N, Afaq F and Mukhtar H: Cancer chemoprevention through dietaryantioxidants: progress and promise. Antioxid Redox Signal 10: 475-570,2008. Featuredon the cover of the journal.
Saleem M, Maddodi N, Zaid MA, Khan N, Hafeez BB, Asim M, Suh Y, Yun JM,Setaluri V and Mukhtar H: Lupeol inhibits growth of highly aggressive humanmetastatic melanoma cells in vitro and in vivo by inducing apoptosis. Clin Cancer Res14: 2119-2127,2008. Featured on the cover of the journal.
Syed DN, Afaq F, Sararaz S, Khan N, Kedlaya R, Setaluri V, Mukhtar H: Delphinidininhibits cell proliferation and ivasion via modulation of Met receptor phosphorylation.Toxicol Appl Phannacol 231: 52-60, 2008. Featured on the cover of the journal.
Afaq F, Zaman N, Khan N, Syed D, Sarfaraz S, Zaid M, Mukhtar H. Inhibition ofepidennal growth factor receptor signaling pathway by delphinidin, an anthocyanidin inpigmented fruits and vegetables. Int. 1. Cancer 123: 1508-15, 2008. Featured on the cover of the journal.
Adhami VM, Siddiqui lA, Sarfaraz S, Khwaja S, Hafeez BB, Ahmad Nand MukhtarH: Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease. Clin Cancer Res (In press).
Murtaza I, Saleem M, Adhami VM, Hafeez BB and Mukhtar H: Suppresion of cFLIPby lupeol, a dietary triterpene, is sufficient to overcome resistance to TRIAL-mediatedapoptosis in chemoresistant human pancreatic cancer cells. Cancer Res 69: 1156-1165,2009.
Siddiqui IA, Adhami VM, Bharali D, Hafeez BB, Asim M, Khwaja S, Ahmad N, CuiH, Mousa Sand Mukhtar H: Introducing nanochemoprevention as a novel approach forcancer control: Proof-of-principle with green tea polyphenol epigallocatechin-3-gallate.Cancer Res (In Press).
American Association for Cancer Research
American Association for the Advancement of Science
American Society for Photobiology
Society for Investigative Dermatology
Society of Toxicology
Charter member, Review committees of VA merit review board on Oncology, American Cancer Society, Study section on Diet , Nutrition and Cancer and member of many NCI, NIAMS, NCCAM and other NIH committees.
Clinical Cancer Research, Cancer Epidemiology Biomarkers and Prevention, Archives of Biochemistry and Biophysics, The Journal of Investigative Dermatology, Toxicology and Applied Pharmacology, Photochemistry and Photobiology, and others.
Reviewer for 55 National and International Peer Reviewed Journals.
Associate Editions: copy for my NIH__
Editorial Boards: for NIH Bio